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Grey’s Anatomy Season 22: What you Should know About Shonda Rhimes’ Returning Medical Drama
Grey’s Anatomy Season 22 is officially on the way, and the buzz is already building. ABC has greenlit another chapter of Shonda Rhimes’ legendary medical drama, making it the longest-running series of its kind — and it’s not slowing down anytime soon.
Season 21 closed with literal and emotional explosions, pushing doctors to their edge and leaving several lives hanging in the balance. A hostage crisis, a desperate surgery, and a final, fiery twist created a cliffhanger so intense, fans are still catching their breath. Now, with the stakes higher than ever, Season 22 promises to pick up the pieces — or shatter them further. One thing’s for sure: Grey Sloan won’t be the same again.
So, what’s next for Meredith’s former crew? From major cast returns to a fresh batch of medical emergencies and emotional chaos, we’ve gathered all the essential intel you need. Keep checking back — we’re updating this guide with every new reveal, tease, and shocking twist as it drops. If you think you’ve seen Grey’s Anatomy at its wildest, Shonda’s next chapter might just raise the scalpel.
Release date & Where to Watch
ABC has confirmed that Grey’s Anatomy will be back in fall 2025 as part of its Thursday primetime lineup. The long-running medical drama will continue airing at 10 pm ET, following 9-1-1 and its new spinoff, 9-1-1: Nashville. Season 22 is set to include 18 episodes, continuing the tradition of high-stakes storytelling fans have come to expect. It will stream on Hulu.
What is Grey's Anatomy Season 22 About?
The exact storyline of Grey’s Anatomy season 22 remains under wraps, but one thing is certain — it’ll pick up after the explosive season 21 finale that left many of Grey Sloan’s doctors in grave danger. The finale set the stage for intense fallout, with a hospital explosion and nearly every character inside during the blast. It has been confirmed that Meredith Grey is alive after he explosion. Along with her, Jason George‘s Warren is also expected to have survived.
Showrunner Meg Marinis revealed in an interview with Variety that Warren was safe. She said, "He was outside the hospital when that explosion went off, so we know he’s alive. But he doesn’t have a job, so he’s going through an emotional explosion."
Co-star Kim Raver described the season 21 ending to TV Insider as: “It is terrifying. It’s so Grey’s… a quintessential finale… such a great springboard into season 22.” Showrunner Meg Marinis also teased what’s next, telling Deadline: “Everybody’s lives could be at stake. Everybody was in that hospital, except for two people, Meredith and Ben… Jo had left the hospital… but if they weren’t outside the hospital, they’re there.”
She added, “Everybody is up for grabs, it’s fun. I won’t comment on if anyone is harmed beyond repair, but it is the best kind of cliffhanger, with the fans screaming at their TVs.”
While it’s tough to predict the plot, it’s safe to assume the new season will dive into fresh medical emergencies, emotional challenges, and the personal lives of the doctors and interns at Grey Sloan. With Meredith likely returning to narrate, and chaos constantly unfolding, viewers can expect a signature blend of heartbreak, heroism, and hallway confessions. From high-stakes surgeries to complicated romances, season 22 promises to keep the drama pulsing.
Who’s in the cast of Grey's Anatomy Season 22?
Here's a look at the expected cast list for Grey's Anatomy season 22 so far:
- Ellen Pompeo as Meredith Grey
- Chandra Wilson as Miranda Bailey
- James Pickens Jr as Richard Webber
- Kevin McKidd as Owen Hunt
- Kim Raver as Teddy Altman
- Camilla Luddington as Jo Wilson
- Caterina Scorsone as Amelia Shepherd
- Jason George as Ben Warren
- Chris Carmack as Atticus Lincoln
- Anthony Hill as Winston Ndugu
- Scott Speedman as Nick Marsh
- Alexis Floyd as Simone Griffith
- Harry Shum Jr as Benson Kwan
- Adelaide Kane as Jules Millin
- Niko Terho as Lucas Adams
- Trevor Jackson
Is There a Trailer for Grey's Anatomy Season 22?
A trailer for Grey’s Anatomy Season 22 hasn’t been released yet, but stay tuned — we’ll update this page the moment any new footage arrives.
Behind the Scenes
Grey's Anatomy's executive producing team includes creator Shonda Rhimes and Betsy Beers of Shondaland as well as current showrunner Meg Marinis along with director and recurring cast member Debbie Allen and Ellen Pompeo. Chandra Wilson who plays Bailey is also a co-executive producer
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